Recent and Selected Publications

2009
Zhang L, McHale CM, Rothman N, Li G, Ji Z, Vermeulen R, Hubbard AE, Ren X, Shen M, Rappaport SM, North M, Skibola CF, Yin S, Vulpe C, Chanock SJ, Smith MT, Lan Q.
Systems biology of human benzene exposure.
Chem Biol Interact. 2009 Dec 21. [Epub ahead of print]

Connon RE, Geist J, Pfeiff J, Loguinov AV, D'Abronzo LS, Wintz H, Vulpe CD, Werner I.
Linking mechanistic and behavioral responses to sublethal esfenvalerate exposure in the endangered delta smelt; Hypomesus transpacificus (Fam. Osmeridae).
BMC Genomics. ;10(1):608. [Epub ahead of print]

Jo WJ, Ren X, Chu F, Aleshin M, Wintz H, Burlingame A, Smith MT, Vulpe CD, Zhang L.
Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure.
Toxicol Appl Pharmacol. 2009 Oct;111(2):424-36. Epub 2009 Jul 27.

Constantine CC, Anderson GJ, Vulpe CD, McLaren CE, Bahlo M, Yeap HL, Gertig DM, Osborne NJ, Bertalli NA, Beckman KB, Chen V, Matak P, McKie AT, Delatycki MB, Olynyk JK, English DR, Southey MC, Giles GG, Hopper JL, Allen KJ, Gurrin LC.
A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis.
Br J Haematol. 2009 Oct;147(1):140-9.

Jo WJ, Loguinov A, Wintz H, Chang M, Smith AH, Kalman D, Zhang L, Smith MT, Vulpe CD.
Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeast.
Toxicol Sci. 2009 Oct;111(2):424-36.

Garcia-Reyero N, Poynton HC, Kennedy AJ, Guan X, Escalon BL, Chang B, Varshavsky J, Loguinov AV, Vulpe CD, Perkins EJ.
Biomarker discovery and transcriptomic responses in Daphnia magna exposed to munitions constituents.
Environ Sci Technol. 2009 Jun 1;43(11):4188-93.

Gurrin LC, Bertalli NA, Dalton GW, Osborne NJ, Constantine CC, McLaren CE, English DR, Gertig DM, Delatycki MB, Nicoll AJ, Southey MC, Hopper JL, Giles GG, Anderson GJ, Olynyk JK, Powell LW, Allen KJ; HealthIron Study Investigators.
HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity.
Hepatology. 2009 Jul;50(1):94-101.

Anderson GJ, Vulpe CD.
Mammalian iron transport.
Cell Mol Life Sci. 2009 Oct;66(20):3241-61.

Chen H, Attieh ZK, Dang T, Huang G, van der Hee RM, Vulpe C.
Decreased hephaestin expression and activity leads to decreased iron efflux from differentiated Caco2 cells.
J Cell Biochem. 2009 Jul 1;107(4):803-8.

Chen H, Attieh ZK, Gao H, Huang G, Su T, Ke W, Vulpe CD.
Age-related changes in iron homeostasis in mouse ferroxidase mutants.
Biometals. 2009 Oct;22(5):827-34.

Jo WJ, Kim JH, Oh E, Jaramillo D, Holman P, Loguinov AV, Arkin AP, Nislow C, Giaever G, Vulpe CD.
Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae.
BMC Genomics. 2009 Mar 25;10:130.

Lan Q, Zhang L, Shen M, Jo WJ, Vermeulen R, Li G, Vulpe C, Lim S, Ren X, Rappaport SM, Berndt SI, Yeager M, Yuenger J, Hayes RB, Linet M, Yin S, Chanock S, Smith MT, Rothman N.
Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.
Carcinogenesis. 2009 Jan;30(1):50-8.

2008
Gurrin LC, Osborne NJ, Constantine CC, McLaren CE, English DR, Gertig DM, Delatycki MB, Southey MC, Hopper JL, Giles GG, Anderson GJ, Olynyk JK, Powell LW, Allen KJ; HealthIron Study Investigators.
The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis.
Gastroenterology. 2008 Dec;135(6):1945-52.

González M, Reyes-Jara A, Suazo M, Jo WJ, Vulpe C.
Expression of copper-related genes in response to copper load.
Am J Clin Nutr. 2008 Sep;88(3):830S-4S.

Poynton HC, Zuzow R, Loguinov AV, Perkins EJ, Vulpe CD.
Gene expression profiling in Daphnia magna, part II: validation of a copper specific gene expression signature with effluent from two copper mines in California.
Environ Sci Technol. 2008 Aug 15;42(16):6257-63.

Poynton HC, Loguinov AV, Varshavsky JR, Chan S, Perkins EJ, Vulpe CD.
Gene expression profiling in Daphnia magna part I: concentration-dependent profiles provide support for the No Observed Transcriptional Effect Level.
Environ Sci Technol. 2008 Aug 15;42(16):6250-6.

Petrak J, Ivanek R, Toman O, Cmejla R, Cmejlova J, Vyoral D, Zivny J, Vulpe CD.
Déjà vu in proteomics. A hit parade of repeatedly identified differentially expressed proteins.
Proteomics. 2008 May;8(9):1744-9.

Constantine CC, Gurrin LC, McLaren CE, Bahlo M, Anderson GJ, Vulpe CD, Forrest SM, Allen KJ, Gertig DM; HealthIron Investigators.
SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis.
BMC Med Genet. 2008 Mar 20;9:18.

Mager EM, Wintz H, Vulpe CD, Brix KV, Grosell M.
Toxicogenomics of water chemistry influence on chronic lead exposure to the fathead minnow (Pimephales promelas).
Aquat Toxicol. 2008 May 1;87(3):200-9.

Allen KJ, Gurrin LC, Constantine CC, Osborne NJ, Delatycki MB, Nicoll AJ, McLaren CE, Bahlo M, Nisselle AE, Vulpe CD, Anderson GJ, Southey MC, Giles GG, English DR, Hopper JL, Olynyk JK, Powell LW, Gertig DM.
Iron-overload-related disease in HFE hereditary hemochromatosis.
N Engl J Med. 2008 Jan 17;358(3):221-30.

Jo WJ, Loguinov A, Chang M, Wintz H, Nislow C, Arkin AP, Giaever G, Vulpe CD.
Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants.
Toxicol Sci. 2008 Jan;101(1):140-51. Erratum in: Toxicol Sci. 2008 Mar;102(1):205.

2007 and earlier
Petrak J, Myslivcova D, Halada P, Cmejla R, Cmejlova J, Vyoral D, Vulpe CD.
Iron-independent specific protein expression pattern in the liver of HFE-deficient mice.
Int J Biochem Cell Biol. 2007;39(5):1006-15.

Poynton HC, Varshavsky JR, Chang B, Cavigiolio G, Chan S, Holman PS, Loguinov AV, Bauer DJ, Komachi K, Theil EC, Perkins EJ, Hughes O, Vulpe CD.
Daphnia magna ecotoxicogenomics provides mechanistic insights into metal toxicity.
Environ Sci Technol. 2007 Feb 1;41(3):1044-50.

Petrak J, Myslivcova D, Man P, Cmejla R, Cmejlova J, Vyoral D, Elleder M, Vulpe CD.
Proteomic analysis of hepatic iron overload in mice suggests dysregulation of urea cycle, impairment of fatty acid oxidation, and changes in the methylation cycle.
Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1490-8.

Wintz H, Yoo LJ, Loguinov A, Wu YY, Steevens JA, Holland RD, Beger RD, Perkins EJ, Hughes O, Vulpe CD.
Gene expression profiles in fathead minnow exposed to 2,4-DNT: correlation with toxicity in mammals.
Toxicol Sci. 2006 Nov;94(1):71-82.

Armendáriz AD, Olivares F, Pulgar R, Loguinov A, Cambiazo V, Vulpe CD, González M.
Gene expression profiling in wild-type and metallothionein mutant fibroblast cell lines.
Biol Res. 2006;39(1):125-42.

Chen H, Huang G, Su T, Gao H, Attieh ZK, McKie AT, Anderson GJ, Vulpe CD.
Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency.
J Nutr. 2006 May;136(5):1236-41.

McGregor JA, Shayeghi M, Vulpe CD, Anderson GJ, Pietrangelo A, Simpson RJ, McKie AT.
Impaired iron transport activity of ferroportin 1 in hereditary iron overload.
J Membr Biol. 2005 Jul;206(1):3-7.

Frazer DM, Wilkins SJ, Vulpe CD, Anderson GJ.
The role of duodenal cytochrome b in intestinal iron absorption remains unclear.
Blood. 2005 Dec 15;106(13):4413.

Anderson GJ, Frazer DM, McKie AT, Vulpe CD, Smith A.
Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism.
Biometals. 2005 Aug;18(4):339-48.

Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, Frazer DM, Anderson GJ, Vulpe CD, Simpson RJ, McKie AT.
Identification of an intestinal heme transporter.
Cell. 2005 Sep 9;122(5):789-801.

Latunde-Dada GO, Vulpe CD, Anderson GJ, Simpson RJ, McKie AT.
Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis.
Biochim Biophys Acta. 2004 Oct 14;1690(2):169-76. Erratum in: Biochim Biophys Acta. 2005 Apr 15;1740(1):91.

Armendariz AD, Gonzalez M, Loguinov AV, Vulpe CD.
Gene expression profiling in chronic copper overload reveals upregulation of Prnp and App.
Physiol Genomics. 2004 Dec 15;20(1):45-54.

Frazer DM, Inglis HR, Wilkins SJ, Millard KN, Steele TM, McLaren GD, McKie AT, Vulpe CD, Anderson GJ.
Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis.
Gut. 2004 Oct;53(10):1509-15.

Frazer DM, Wilkins SJ, Millard KN, McKie AT, Vulpe CD, Anderson GJ.
Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE.
Br J Haematol. 2004 Aug;126(3):434-6.

Loguinov AV, Mian IS, Vulpe CD.
Exploratory differential gene expression analysis in microarray experiments with no or limited replication.
Genome Biol. 2004;5(3):R18. Epub 2004 Mar 1.

Kuo YM, Su T, Chen H, Attieh Z, Syed BA, McKie AT, Anderson GJ, Gitschier J, Vulpe CD.
Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse.
Gut. 2004 Feb;53(2):201-6.

Chen H, Su T, Attieh ZK, Fox TC, McKie AT, Anderson GJ, Vulpe CD.
Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency.
Blood. 2003 Sep 1;102(5):1893-9.